KPV
KPV
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Product details
KPV is a synthetic tripeptide corresponding to the C-terminal fragment of alpha-melanocyte-stimulating hormone (alpha-MSH). It belongs to the melanocortin-derived tripeptide class.
In the published preclinical literature, KPV has been characterised at the molecular and cellular level: in cultured epithelial and immune cell models it is described as entering cells through the di- and tripeptide transporter PepT1 and as associating with the NF-kappaB and MAP kinase signalling pathways, with work also separating PepT1-mediated transport from melanocortin-receptor signalling. It is supplied as a research compound and is not intended for human or veterinary use.
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supplied for laboratory research only
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Research
KPV has been characterised in preclinical laboratory models. The primary studies below, in cultured cell models, examined cellular signalling endpoints, with the work centred on the melanocortin-derived tripeptide and the C-terminal fragment of alpha-MSH. The literature is preclinical; it describes the compound, not any outcome in humans.
2 preclinical studies indexed · cell-signalling models · links open on PubMed
Cell-signalling models 2 studies
In vitro
alpha-Melanocyte-stimulating hormone, MSH 11-13 KPV and adrenocorticotropic hormone signalling in keratinocyte cells
In cultured keratinocytes, the study measured intracellular calcium and cyclic AMP responses to MSH 11-13 (KPV) and related peptides, mapping the signalling pathways the tripeptide engages in vitro.
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In vitro
Immobilized alpha-melanocyte stimulating hormone 10-13 (GKPV) inhibits tumor necrosis factor-alpha stimulated NF-kappaB activity
In cultured HBL cells carrying an NF-kappaB-luciferase reporter, the study assayed NF-kappaB reporter activity under tumour-necrosis-factor-alpha stimulation, comparing immobilized GKPV (the KPV-containing alpha-MSH fragment) against the soluble peptide as a measured cell-signalling endpoint.
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Links open the original study on PubMed. For research and educational purposes, descriptive of the published preclinical literature, not therapeutic claims about any ai-peptides product. A Certificate of Analysis and a Safety Data Sheet are available on request for every batch.
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