Testagen is a short, bioregulatory peptide that primarily affects the pituitary gland and, subsequently, the thyroid gland. By acting on these glands, Testagen may help normalize testosterone and thyroid hormone production in specific scenarios. Through its influence on thyroid function, it also has a moderate impact on the immune system. Testagen is often viewed as a peptide that can “reset” the pituitary to a more youthful state, making it of interest in anti-aging research. Current studies explore its potential to boost testosterone, enhance thyroid function, and promote stem cell differentiation to support immune health.
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This product is intended as a research chemical only. Not for human use. Peptides will arrive in a lyophilized (powder) form for maximum stability.
Testagen, as its name suggests, is a testosterone-boosting bioregulatory peptide. Like many short peptides, it can cross both the cellular and nuclear membranes to interact directly with DNA. Research indicates that Testagen stimulates the anterior pituitary gland to increase the release of thyroid-stimulating hormone (TSH), which in turn elevates T3 and T4 thyroid hormone levels. Notably, it does so even in the absence of hypothalamic support, suggesting it directly alters protein expression patterns within the pituitary. This mechanism may also help explain its impact on testosterone production. Additionally, because Testagen acts on the pituitary gland, it influences both hemostasis and immune function, though these effects are less significant than its impact on thyroid and testosterone levels.
Molecular Formula: C₁₇H₂₉N₅O₉
Molecular Weight: 447.2 g/mol
Testagen is a short, bioregulatory peptide with a primary focus on the pituitary and thyroid glands. Through its regulatory effects on these endocrine systems, Testagen has been shown in research to potentially normalize testosterone production and support thyroid hormone output. These effects are believed to occur due to Testagen’s ability to alter DNA expression patterns within the pituitary gland, stimulating increased secretion of thyroid-stimulating hormone (TSH), which can restore T3 and T4 levels even in cases of hypothalamic or pituitary dysfunction.
By resetting the pituitary gland to a more youthful state, Testagen has demonstrated potential as an anti-aging peptide. Research indicates that it may play a role in restoring hormonal balance, particularly in aging individuals with testosterone decline, potentially aiding in conditions like reduced bone density, muscle mass loss, erectile dysfunction, cognitive difficulties, and low energy levels. Notably, the interplay between thyroid and testosterone levels has been well documented, with low thyroid hormone levels often resulting in reduced testosterone—suggesting that Testagen’s benefits on testosterone may stem from its thyroid-regulating properties.
In addition to its hormonal effects, Testagen has shown promising outcomes in immune system support. Studies led by Prof. Vladimir Khavinson suggest that Testagen can enter the nucleus of cells and directly influence gene expression, specifically genes involved in cell differentiation. This includes stimulation of stem cells into immune-related cells, which may be especially valuable in older individuals experiencing immune senescence. The connection between thyroid hormone function and immune health further supports Testagen’s immunomodulatory potential.
Early research, including work from Dr. Boris Kuznik, also explores Testagen’s impact on hemostasis (blood clotting), with indications that it may normalize clotting function in certain pathological states. Though not a direct immune function, blood coagulation is closely regulated alongside thyroid function and may benefit from Testagen’s regulatory mechanisms.
Testagen has demonstrated good oral and excellent subcutaneous bioavailability in mice, with minimal observed side effects. However, per-kilogram dosing in animal models does not directly translate to human applications. It is important to note that Testagen is currently being studied in preclinical and experimental settings and has not been approved by the FDA for any medical use.
The above literature was researched, edited, and organized by Dr. E. Logan, M.D.
Dr. Logan holds a doctorate from Case Western Reserve University School of Medicine and a B.S. in Molecular Biology.
Prof. Vladimir Khavinson is a renowned scientist in the field of gerontology and peptide bioregulation. He is the President of the European Region of the International Association of Gerontology and Geriatrics, a member of both the Russian and Ukrainian Academies of Medical Sciences, and the Director of the St. Petersburg Institute of Bioregulation and Gerontology. With over 775 scientific publications and 196 patents, his work has led to the development of 6 peptide-based pharmaceuticals and 64 peptide supplements.
Prof. Khavinson is credited with pioneering the field of peptide geroprotectors—compounds designed to slow aging and extend lifespan. His major works include the books “Peptides and Ageing” and “Gerontological Aspects of Genome Peptide Regulation.” He has overseen over 200 doctoral theses and introduced the specialty of Gerontology and Geriatrics in Russia at the governmental level.
Kuznik, B. I., Pateiuk, A. V., Rusaeva, N. S., Baranchugova, L. M., & Obydenko, V. I.
Effects of hypophyseal Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly synthetic peptides on immunity, hemostasis, morphology and functions of the thyroid gland in neonatally hypophysectomized chicken and one-year-old birds.
Patol. Fiziol. Eksp. Ter., No. 1, pp. 14–18, Mar. 2010.
PubMed
Kuznik, B. I., Pateiuk, A. V., Rusaeva, N. S., Baranchugova, L. M., & Obydenko, V. I.
Effects of Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly peptides on hormonal activity and thyroid morphology in hypophysectomized mature and old birds.
Adv. Gerontol. Uspekhi Gerontol., Vol. 24, No. 1, pp. 93–98, 2011.
PubMed
Meikle, A. W.
The interrelationships between thyroid dysfunction and hypogonadism in men and boys.
Thyroid, Vol. 14 Suppl 1, pp. S17–S25, 2004.
DOI: 10.1089/105072504323024552
Fedoreyeva, L. I., Kireev, I. I., Khavinson, V. K., & Vanyushin, B. F.
Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA.
Biochemistry (Moscow), Vol. 76, No. 11, Nov. 2011.
DOI: 10.1134/S0006297911110022
Khavinson, V., Linkova, N., Diatlova, A., & Trofimova, S.
Peptide Regulation of Cell Differentiation.
Stem Cell Rev. Rep., Vol. 16, No. 1, pp. 118–125, Feb. 2020.
DOI: 10.1007/s12015-019-09938-8
All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months.
Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days.
Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you’re ready to reconstitute it with bacteriostatic water.
Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4C (39F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.
However, for longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80C (-112F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide’s stability.
For further information on proper storage techniques, click the link below:
Peptide Storage Information
This product is intended as a research chemical only. Not for human use. Peptides will arrive in a lyophilized (powder) form for maximum stability.
Testagen, as its name suggests, is a testosterone-boosting bioregulatory peptide. Like many short peptides, it can cross both the cellular and nuclear membranes to interact directly with DNA. Research indicates that Testagen stimulates the anterior pituitary gland to increase the release of thyroid-stimulating hormone (TSH), which in turn elevates T3 and T4 thyroid hormone levels. Notably, it does so even in the absence of hypothalamic support, suggesting it directly alters protein expression patterns within the pituitary. This mechanism may also help explain its impact on testosterone production. Additionally, because Testagen acts on the pituitary gland, it influences both hemostasis and immune function, though these effects are less significant than its impact on thyroid and testosterone levels.
Molecular Formula: C₁₇H₂₉N₅O₉
Molecular Weight: 447.2 g/mol
Testagen is a short, bioregulatory peptide with a primary focus on the pituitary and thyroid glands. Through its regulatory effects on these endocrine systems, Testagen has been shown in research to potentially normalize testosterone production and support thyroid hormone output. These effects are believed to occur due to Testagen’s ability to alter DNA expression patterns within the pituitary gland, stimulating increased secretion of thyroid-stimulating hormone (TSH), which can restore T3 and T4 levels even in cases of hypothalamic or pituitary dysfunction.
By resetting the pituitary gland to a more youthful state, Testagen has demonstrated potential as an anti-aging peptide. Research indicates that it may play a role in restoring hormonal balance, particularly in aging individuals with testosterone decline, potentially aiding in conditions like reduced bone density, muscle mass loss, erectile dysfunction, cognitive difficulties, and low energy levels. Notably, the interplay between thyroid and testosterone levels has been well documented, with low thyroid hormone levels often resulting in reduced testosterone—suggesting that Testagen’s benefits on testosterone may stem from its thyroid-regulating properties.
In addition to its hormonal effects, Testagen has shown promising outcomes in immune system support. Studies led by Prof. Vladimir Khavinson suggest that Testagen can enter the nucleus of cells and directly influence gene expression, specifically genes involved in cell differentiation. This includes stimulation of stem cells into immune-related cells, which may be especially valuable in older individuals experiencing immune senescence. The connection between thyroid hormone function and immune health further supports Testagen’s immunomodulatory potential.
Early research, including work from Dr. Boris Kuznik, also explores Testagen’s impact on hemostasis (blood clotting), with indications that it may normalize clotting function in certain pathological states. Though not a direct immune function, blood coagulation is closely regulated alongside thyroid function and may benefit from Testagen’s regulatory mechanisms.
Testagen has demonstrated good oral and excellent subcutaneous bioavailability in mice, with minimal observed side effects. However, per-kilogram dosing in animal models does not directly translate to human applications. It is important to note that Testagen is currently being studied in preclinical and experimental settings and has not been approved by the FDA for any medical use.
The above literature was researched, edited, and organized by Dr. E. Logan, M.D.
Dr. Logan holds a doctorate from Case Western Reserve University School of Medicine and a B.S. in Molecular Biology.
Prof. Vladimir Khavinson is a renowned scientist in the field of gerontology and peptide bioregulation. He is the President of the European Region of the International Association of Gerontology and Geriatrics, a member of both the Russian and Ukrainian Academies of Medical Sciences, and the Director of the St. Petersburg Institute of Bioregulation and Gerontology. With over 775 scientific publications and 196 patents, his work has led to the development of 6 peptide-based pharmaceuticals and 64 peptide supplements.
Prof. Khavinson is credited with pioneering the field of peptide geroprotectors—compounds designed to slow aging and extend lifespan. His major works include the books “Peptides and Ageing” and “Gerontological Aspects of Genome Peptide Regulation.” He has overseen over 200 doctoral theses and introduced the specialty of Gerontology and Geriatrics in Russia at the governmental level.
Kuznik, B. I., Pateiuk, A. V., Rusaeva, N. S., Baranchugova, L. M., & Obydenko, V. I.
Effects of hypophyseal Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly synthetic peptides on immunity, hemostasis, morphology and functions of the thyroid gland in neonatally hypophysectomized chicken and one-year-old birds.
Patol. Fiziol. Eksp. Ter., No. 1, pp. 14–18, Mar. 2010.
PubMed
Kuznik, B. I., Pateiuk, A. V., Rusaeva, N. S., Baranchugova, L. M., & Obydenko, V. I.
Effects of Lys-Glu-Asp-Gly and Ala-Glu-Asp-Gly peptides on hormonal activity and thyroid morphology in hypophysectomized mature and old birds.
Adv. Gerontol. Uspekhi Gerontol., Vol. 24, No. 1, pp. 93–98, 2011.
PubMed
Meikle, A. W.
The interrelationships between thyroid dysfunction and hypogonadism in men and boys.
Thyroid, Vol. 14 Suppl 1, pp. S17–S25, 2004.
DOI: 10.1089/105072504323024552
Fedoreyeva, L. I., Kireev, I. I., Khavinson, V. K., & Vanyushin, B. F.
Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA.
Biochemistry (Moscow), Vol. 76, No. 11, Nov. 2011.
DOI: 10.1134/S0006297911110022
Khavinson, V., Linkova, N., Diatlova, A., & Trofimova, S.
Peptide Regulation of Cell Differentiation.
Stem Cell Rev. Rep., Vol. 16, No. 1, pp. 118–125, Feb. 2020.
DOI: 10.1007/s12015-019-09938-8
All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months.
Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days.
Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you’re ready to reconstitute it with bacteriostatic water.
Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4C (39F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.
However, for longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80C (-112F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide’s stability.
For further information on proper storage techniques, click the link below:
Peptide Storage Information
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