BPC-157

How Does BPC 157 Work?

BPC 157 is a derivative of a natural protein called body protection compound (BPC). BPC was first isolated from the digestive system where it plays an important role in protecting the stomach lining from stomach acid. Research has since revealed that the healing properties of BPC 157 extend well beyond the gut. The peptide has been shown to boost wound healing in a variety of tissues, increase the rate of blood vessel growth, improve blood clotting, and enhance the immune system.To understand how BPC 157 can have such wide-ranging effects, it is necessary to start at the most basic level of its activity to see how its properties build upon one another to create an excellent healing peptide.

How Does BPC 157 Work in Blood Vessels?

Research shows that BPC 157 works in two different ways in blood vessels. First, it helps blood vessels to relax so that blood flows more easily through them. It does this by increasing concentrations of a natural compound called nitric oxide. Nitric oxide is critical to not just maintaining blood pressure, but to maintaining the health of the endothelial cells that line blood vessels. (11)

BPC 157 Arginate vs BPC 157 Acetate

Another way to evaluate the quality of a BPC 157 source is to look at whether the seller understands the difference between the arginate and acetate versions of the peptide. BPC 157 acetate is a slightly modified version of the natural peptide that provides for increased shelf-life and better resistance to the extremes of shipping environments. BPC 157 acetate is commonly used for subcutaneous injection as it is degraded in the GI tract to such an extent that nearly 98% of it is gone after just a short time in gastric acid.For researchers interested in understanding the effects of oral administration of BPC 157, then the arginate salt is preferred. BPC 157 arginate retains the superior shipping and storage properties of BPC 157 acetate, but is also stable in gastric acid for extended periods. Research shows that just 10% of BPC 157 arginate is degraded after 5 hours in gastric acid.BPC 157 arginate is sometimes referred to as “stable BPC 157.” This is a correct usage of the term stable, but it is important for anyone looking to buy BPC 157 that they specify whether the seller is referring to BPC 157 arginate or acetate as the two peptides are both “stable” depending on context.

What Is BPC 157?

If you are looking to purchase BPC 157, you likely already know what the peptide is and the research that has been done on it. Still, it is important to cover this topic broadly so that you can evaluate whether the BPC 157 source you are considering buying BPC 157 from is reliable or not.

BPC 157 is a synthetically produced peptide based off of the naturally occurring body protection compound (BPC) protein that was isolated from human gastric contents. This short peptide has been shown to have both anti-inflammatory and wound healing effects not just in the gastrointestinal system, but in musculoskeletal and neurological tissue as well. BPC 157 also promotes the growth of blood vessels and is thought to help maintain homeostasis.

Research on BPC 157 has focused primarily on its wound healing properties. It has undergone phase 1 clinical trials and has been investigated as a potential treatment for tendon injury, inflammatory bowel disease, and accelerating the rate of fistula healing.

BPC 157 is a peptide that has demonstrated anti-inflammatory, cytoprotective, and endothelial-protective effects in different organ systems in different species. BPC 157 activated endothelial nitric oxide synthase (eNOS) is associated with nitric oxide (NO) release, tissue repair and angio-modulatory properties which can lead to improved vascular integrity and immune response, reduced proinflammatory profile, and reduced critical levels of the disease. As a result, discussion of its use as a potential prophylactic and complementary treatment is critical.

Figure 2: BPC 157 Molecule

Researchers hypothesize BPC 157 to be a promising future treatment for COVID-19 patients. Plausibly, BPC 157 may offer improved COVID-19 outcomes by mitigating cytokine derailment and subsequent multi-organ failure based on its anti-inflammatory, cytoprotective, and endothelium-protecting effects (e.g., through BPC 157-eNOS interactions). Furthermore, BPC 157 applications may obstruct viral replication, improve clinical and biochemical parameters, attenuate organ damage from the systemic alterations, provoked from SARS-CoV-2. Support for such a hypothesis is explained in further detail below.

BPC-157 is a partial form of the protein known as body protection compound (BPC). BPC is a natural component within the body and has been found, in experiments on animals, to promote healing. BPC is not just active in intestinal repair and healing, but appears to produce similar effects in a number of tissues. Scientific studies based on animal test subjects has shown that its healing actions are at least partially linked to growth hormone (GH).

Multi-Organ Membrane Repair and Dopamine Balancing.

“Pentadecapeptide BPC 157 antagonizes the incidence of a series of gastrointestinal lesions, it has a positive impact on the healing processes of various wounds, a proven angiogenic effect, protective effect on endothelium and it modulates synthesis of NO.” (1)”Apart from the effects on various gastrointestinal lesions, the potentially beneficial effect on pancreas, liver injuries, endothelium and heart damage, i.e. dysrhythmias following reoxygenation, and blood pressure, along with effect on experimental acute/chronic inflammation, wound and fracture (pseudoarthrosis) healing are described. It appears that these beneficial effects all together provide a particular network reflecting activity of a special peptidergic defence system.” (4)”In support of this concept, it appears that there are interactions of this pentadecapeptide with many important systems (namely, dopamine-, NO-, prostaglandin-, somatosensory neurone-systems), that could provide a basis for the observed protective effects. Moreover, since disturbance of these systems’ functions (i.e. dopamine-, NO-, somatosensory neuronal-system) which manifest either over-activity or as inhibition, may contribute to the multiple lesions in different organs. The reported evidence that this pentadecapeptide is able to counteract both their over-action, and their inhibition, may suggest this pentadecapeptide as a new, but most probably essential physiological defence system and that should be further investigated.” (4)

Osteoporosis is the most prevalent systemic skeletal system disease, leading to increased bone fragility and vulnerability to fractures. Due to the microarchitectural destruction in bone tissue, fracture healing in osteoporoti patients is often delayed and compromised compared with non‑osteoporotic individuals. Osteoporosis usually results from meno‑ pause, aging, metabolic diseases and drug therapies with the precise cellular and molecular mechanism remaining to be elucidated.

Recent studies have shown that four peptides (BPC-157, AOD 9604, MOTS-c, Peptide 11R‐VIVIT) have been proven to have healing effects for such disease in several types of model… High concentration and long-term stimulation of TGF-β1 induced osteogenic differentiation of bone marrow mesenchymal stem cells (MSCs) in vitr2. TGF-β pathway-related genes exert anti-osteoporosis effects by regulating the function of bone deposits and osteoclasts. TGF-β also affects the bone formation by promoting the proliferation and differentiation of osteoblasts, as well as the synthesis of extracellular matrix.

BPC-157 vs TB-500

BPC-157 and TB-500 are both potent healing peptides with vast amounts of research investigating their properties and potential uses. Both are also synthetic derivatives of naturally occurring proteins that have been modified to enhance their already abundant features. Both peptides have been shown to improve immune function, enhance healing throughout the body, and even thwart the ravages of age in some ways. Still, BPC-157 vs TB-500 is a valid comparison as these two peptides are not the same and do not share all of the same functions. Below is a look at why someone might choose BPC-157 over TB-500 or vice versa.

BPC-157 vs TB-500: General Wound Healing

Both TB-500 and BPC-157 have been shown to accelerate wound healing and tissue repair. BPC-157, a derivative of body protection compound (BPC), has a dose-dependent effect on the growth and migration of fibroblasts, the cells responsible for extracellular matrix repair[1]. TB-500, a derivative of thymosin beta-4 (Tβ-4) has a similar effect that it produces by manipulating actin filaments. Actin is a protein that plays central roles in cell reproduction and migration. Research shows that TB-500 can increase the rate of fibroblast growth and migration as well as boost health and migration of cells of the immune system.

What is BPC-157?

BPC-157 is a partial sequence of body protection compound (BPC) found in human gastric juice. It is mostly used in research to accelerate healing of a variety of wounds including tendon-to-bone healing and healing of damaged ligaments. This peptide acts systematically in the digestive tract to combat leaky gut, IBS, gastrointestinal cramps, and Crohn’s disease. In addition, BPC-157 can protect and prevent ulcers, and it can be used to protect the liver from toxic damage from alcohol, antibiotics, etc. This peptide has also been promising in promoting the healing of traumatic brain injury (TBI) according to research.