GH Releasers

Tesamorelin is a growth hormone releasing hormone (GHRH) analogue approved by the FDA for use in HIV-associated lipodystrophy. Because it increases growth hormone (GH) levels, tesamorelin can increase lean body mass, improve bone strength, burn fat, and even enhance immune function. It is the fat burning properties of tesamorelin, however, that are of greatest interest in the clinical setting. Tesamorelin is also known for its ability to improve peripheral nerve regeneration and is under investigation as a potential treatment for mild cognitive impairment (MCI). Tesamorelin has been in clinical use since 2010. Because of its long production history and relatively simple to produce characteristics, tesamorelin cost is one of the lowest among the GHRH analogues.

Purification Steps Determine Tesamorelin Cost

The cost of producing peptides generally comes from the purification and lyophilization steps of the process and not from the actual peptide synthesis. This was not always the case and producing larger peptides like tesamorelin cost quite a lot in the past. With advances in scalable synthesis, however, the production costs of many peptides have come down dramatically. This is particularly true for peptides, like tesamorelin, that require some degree of modification from their “normal” or standard counterpart[1]. In short, tesamorelin cost has declined significantly as manufacturing processes have advanced. While the purification step currently represents the bulk of the cost to manufacture tesamorelin, that is only because the cost of all of the other steps has been reduced so dramatically.

Ipamorelin and CJC-1295 are amongst the most heavily researched growth hormone secretagogues. While ipamorelin acts at the ghrelin receptor, CJC-1295 acts at the growth hormone releasing hormone (GHRH) receptor. This fact alone makes the combination of these peptides popular in research investigating how both high and widened growth hormone (GH) peaks might work synergistically to produce enhanced effects while limiting side effects. Fortunately, the Ipamorelin/CJC-1295 cost point remains low because both peptides are well established and therefore affordable.

Ipamorelin/CJC-1295 Cost

There are two ways to look at the Ipamorelin/CJC-1295 cost paradigm. On the one hand, using two GH secretagogues together may seem like some to be overkill. After all, both will cause relatively physiologic increases in GH levels to increase muscle and bone mass while decreasing fat mass. It would seem that money can be conserved by simply choosing either the highly specific ipamorelin with its enhanced bone benefits or the equally selective CJC-1295 with its long half-life.

On the other hand, however, is the argument that Ipamorelin/CJC-1295 cost, even when both peptides are combined, is both affordable in and of itself, but almost a steal when the effects of the two peptides are combined. After all, while CJC-1295 causes enhanced peaks when used alone, it can cause both doubly enhanced peaks and higher troughs as a result of a higher baseline when used with ipamorelin[1]. In other words, the peptides work together to drastically elevate GH levels into a stratosphere that cannot be achieved, even with large doses, when using the two peptides alone. Thus, if the goal is to study the benefits of vastly enhanced growth hormone secretion, the cheapest and only way to get it is with the Ipamorelin/CJC-1295 combination.