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Repair and Recovery Research

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.

What is BPC-157 Peptide?

What is BPC-157?

BPC-157 is a partial sequence of body protection compound (BPC) found in human gastric juice. It is mostly used in research to accelerate healing of a variety of wounds including tendon-to-bone healing and healing of damaged ligaments. This peptide acts systematically in the digestive tract to combat leaky gut, IBS, gastrointestinal cramps, and Crohn’s disease. In addition, BPC-157 can protect and prevent ulcers, and it can be used to protect the liver from toxic damage from alcohol, antibiotics, etc. This peptide has also been promising in promoting the healing of traumatic brain injury (TBI) according to research.

BPC-157 vs TB-500

BPC-157 vs TB-500

BPC-157 and TB-500 are both potent healing peptides with vast amounts of research investigating their properties and potential uses. Both are also synthetic derivatives of naturally occurring proteins that have been modified to enhance their already abundant features. Both peptides have been shown to improve immune function, enhance healing throughout the body, and even thwart the ravages of age in some ways. Still, BPC-157 vs TB-500 is a valid comparison as these two peptides are not the same and do not share all of the same functions. Below is a look at why someone might choose BPC-157 over TB-500 or vice versa. 

BPC-157 vs TB-500: General Wound Healing

Both TB-500 and BPC-157 have been shown to accelerate wound healing and tissue repair. BPC-157, a derivative of body protection compound (BPC), has a dose-dependent effect on the growth and migration of fibroblasts, the cells responsible for extracellular matrix repair[1]. TB-500, a derivative of thymosin beta-4 (Tβ-4) has a similar effect that it produces by manipulating actin filaments. Actin is a protein that plays central roles in cell reproduction and migration. Research shows that TB-500 can increase the rate of fibroblast growth and migration as well as boost health and migration of cells of the immune system.

TB-500 (Thymosin Beta-4) Peptide Research

TB-500 also known as Thymosin Beta 4 is a naturally occurring peptide. It is found in high concentrations in blood platelets, wound fluid and other tissues in the body. TB-500 is not a growth factor; rather, it is a major actin regulating peptide. TB-500 (Thymosin Beta 4) has been found to play an important role in protection, regeneration and remodeling of injured or damaged tissues. The gene for TB-500 (Thymosin Beta 4) has also been found to be one of the first to be upregulated after a wound occurs.

How does Thymosin Beta 4 (TB-500) enhance hair follicle growth?

Thymosin Beta 4 Increases Hair Growth by Activating Hair Follicle Stem Cells.

“Thymosin β4, a ubiquitous 4.9‐kDa polypeptide originally isolated from bovine thymus, is a potent mediator of cell migration and differentiation. It was identified as a gene up‐ regulated four‐ to sixfold during early endothelial cell tube formation and found to promote angiogenesis. It is present in wound fluid, and when added topically or given systemically, it promotes angiogenesis and wound healing. Thymosin β4 elicits cell migration through a specific interaction with actin. In angiogenesis and in wound healing, thymosin β4 acts by accelerating the migration of endothelial cells and keratinocytes and increasing the production of extracellular matrix‐degrading enzymes.”
“Thymosin β4 promotes hair growth in normal rats and mice. A specific subset of follicular keratinocytes in the mouse skin, which originates at the bulge region, expresses thymosin β4. The temporal and spatial distribution of these keratinocytes parallel the pattern reported for the stem cells and their daughter TA cells at the different stages of the hair cycle (910). We isolated clonogenic keratinocytes from the bulge compartment of the rat vibrissa follicle, further characterized them as an immediate progeny of the stem cells, and found that these cells express high levels of thymosin β4 when cultured in vitro. We show that thymosin β4 promotes hair clonogenic keratinocyte cell migration, as well as secretion of the extracellular matrix‐degrading enzyme matrix metalloproteinase 2 (MMP‐2).””Thus, thymosin β4 accelerates hair growth, in part, due to its effect on critical events in the active phase of the hair follicle cycle, including promoting the migration of stem cells and their immediate progeny to the base of the follicle, differentiation, and extracellular matrix remodeling.”
“Taken together, our results suggest that in addition to its known angiogenic and wound healing effects, thymosin β4 is a naturally occurring modulator of hair growth that acts by stimulation of stem cell migration, protease production, and differentiation.”

“While studying wound healing in rat skin, we unexpectedly observed visually and at the histological level increased hair growth at the wound margins 7 days after topical treatment with thymosin β4 (unpublished observation). In this study, we have shaved the skin of healthy rats and applied thymosin β4 topically on one side of the shaved area and the control vehicle on the opposing lateral side of the same animal. After 7 days of treatment, we observed an increased number of anagen‐phase hair follicles in the skin areas treated with thymosin β4 (Fig. 1a and d). The number of anagen follicles was approximately twofold greater than in rats treated with vehicle alone. The increased number of hairs in anagen phase was retained with continued tri‐ weekly treatment over 30 days. Within 14 days of treatment cessation, the number of active hair follicles decreased to control levels. We next tested whether thymosin β4 would promote hair growth in 8‐wk‐old C57BL6 wild‐type mice. Animals used in this experiment have all of their hair follicles in the telogen stage as judged by their pink skin color. The mice were shaved and thymosin β4 was applied topically on the shaved area as described in Methods. Control animals were treated with vehicle alone. As shown in Fig. 1c and ƒ, thymosin β4‐treated (but not control) animals displayed quick hair regrowth. Histological examination confirmed the thymosin β4‐induced activation of the hair follicles (Fig. 1b and e).”

Peptides BPC157, AOD9604, MOTS-c improve Bone Mineral Density for Osteoporosis.

Osteoporosis is the most prevalent systemic skeletal system disease, leading to increased bone fragility and vulnerability to fractures. Due to the microarchitectural destruction in bone tissue, fracture healing in osteoporoti patients is often delayed and compromised compared with non‑osteoporotic individuals. Osteoporosis usually results from meno‑ pause, aging, metabolic diseases and drug therapies with the precise cellular and molecular mechanism remaining to be elucidated.

Recent studies have shown that four peptides (BPC-157, AOD 9604, MOTS-c, Peptide 11R‐VIVIT) have been proven to have healing effects for such disease in several types of model… High concentration and long-term stimulation of TGF-β1 induced osteogenic differentiation of bone marrow mesenchymal stem cells (MSCs) in vitr2. TGF-β pathway-related genes exert anti-osteoporosis effects by regulating the function of bone deposits and osteoclasts. TGF-β also affects the bone formation by promoting the proliferation and differentiation of osteoblasts, as well as the synthesis of extracellular matrix.

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