MK 677 Benefits
MK 677Â (a.k.a. Ibutamoren, Oratrope, Crescendo) is a selective ghrelin (growth hormone secretagogue) receptor agonist. Research shows that it increases secretion of growth hormone (GH) and insulin-like growth factor 1 (IGF-1). Research has shown the major MK 677 benefit is that it activates the growth hormone axis without increasing levels of cortisol. MK 677 promotes a lean body composition by favoring muscle and bone deposition while simultaneously increasing fat burning. It is being investigated as a potential treatment for GH deficiency, certain bone and muscle conditions, disordered sleep, and as an appetite stimulant.
MK 677 Does Not Increase Cortisol
Cortisol is a steroid hormone known to suppress inflammation and increase the production of sugar in the liver. It is an important hormone for immune function and electrolyte balance, but too much of it leads to fat deposition, bone loss, high blood sugar, immune suppression, and muscle wasting. Some growth hormone secretagogue receptor agonists can increase cortisol levels, which dampens their positive effects. One MK 677 benefit, a result of its high specificity, is that it does not increase cortisol levels. Thus, the benefits of MK 677 in stimulating the GH axis are not offset by concomitant stimulation of cortisol release.
