Brief overview/Summary
Cellular senescence is a natural process with both protective and harmful effects. Throughout life, senescence helps prevent tumor formation and mitigate tissue damage. However, as individuals age, senescent cells accumulate in tissues, potentially contributing to various age-related diseases. Recent research has uncovered the molecular mechanisms that support the survival of senescent cells and regulate their immune clearance. These findings provide a foundation for developing new therapeutic approaches to target senescent cells while highlighting the importance of understanding the limitations, efficacy, safety, and potential risks of current strategies for senescent cell elimination. This article explores existing methods for targeting senescent cells and the challenges in advancing these strategies into safe and effective therapies. Successfully addressing these challenges could revolutionize treatments for age-related diseases and transform the way we approach health management during aging.
