Epithalon
Epithalon
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Product details
Epithalon is a synthetic tetrapeptide with the amino-acid sequence alanyl-glutamyl-aspartyl-glycine. It belongs to the short synthetic peptide class and was developed as a synthetic analogue of a pineal peptide preparation.
In the published preclinical literature, Epithalon has been characterised at the molecular level for its sequence-specific binding to short DNA oligonucleotides and, in cultured cell and animal-cell models, for its association with telomerase enzyme activity and with gene-expression markers measured by molecular-biology methods. It is supplied as a research compound and is not intended for human or veterinary use.
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Research
Epithalon has been characterised in preclinical laboratory models. The primary studies below, in a cell line with isolated DNA and in a bovine cell model, examined molecular and cellular endpoints, with the work centred on the tetrapeptide’s sequence-specific DNA binding and on telomerase enzyme activity assayed in culture. The literature is preclinical; it describes the compound, not any outcome in humans.
2 preclinical studies indexed · molecular and cell-culture models · links open on PubMed
Molecular and cell-culture models 2 studies
In vitro
Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA
Using fluorescence-quenching constants on isolated deoxyribooligonucleotides and DNA, the study measured the sequence-specific binding of the tetrapeptide Ala-Glu-Asp-Gly, reporting a preference for CNG and CAG-containing sequences and a sensitivity to cytosine methylation status, alongside nuclear penetration assayed in a HeLa cell line.
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Animal cell model
Epitalon-activated telomerase enhance bovine oocyte maturation rate and post-thawed embryo development
In a bovine in-vitro oocyte and embryo-culture model, the study assayed telomerase protein level and localisation by immunofluorescence and measured gene expression by quantitative PCR, reactive-oxygen-species level, and mitochondrial membrane potential as molecular endpoints of the peptide’s effect on telomerase activity.
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Links open the original study on PubMed. For research and educational purposes, descriptive of the published preclinical literature, not therapeutic claims about any ai-peptides product. A Certificate of Analysis and a Safety Data Sheet are available on request for every batch.
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