Pathway-3 Research Set
Pathway-3 Research Set
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Product details
Pathway-3 Research Set is supplied for qualified laboratory research use only.
Product documentation may include identity, nominal fill, purity, lot number, retest or expiry date, and a lot-specific Certificate of Analysis (COA), where available.
Not intended for diagnostic, therapeutic, clinical, food, cosmetic, household, or personal-use applications. Not intended for use outside qualified laboratory research.
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supplied for laboratory research only
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Research
Each compound in this set has been characterised in preclinical laboratory models. The primary studies below, in animal and in-vitro models, examined cellular, biochemical, and mechanistic endpoints. The literature is preclinical: it describes the compounds, not any outcome in humans.
3 preclinical studies indexed · kisspeptin · links open on PubMed
Kisspeptin 3 studies
In vitro
The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54
In Chinese hamster ovary cells expressing GPR54, the study measured low-nanomolar binding of kisspeptin to the receptor and quantified receptor activation as PIP2 hydrolysis, calcium mobilisation, arachidonic-acid release, and ERK1/2 and p38 MAP-kinase phosphorylation as molecular endpoints.
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Animal model
Kisspeptin excites gonadotropin-releasing hormone neurons through a phospholipase C and calcium-dependent pathway regulating multiple ion channels
In acute brain slices from transgenic mice, perforated-patch electrophysiology and calcium imaging recorded the firing of gonadotropin-releasing-hormone neurons and mapped the kisspeptin response to a phospholipase C and calcium-dependent pathway acting on multiple ion channels as electrophysiological endpoints.
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Animal model
Kisspeptin depolarizes gonadotropin-releasing hormone neurons through activation of TRPC-like cationic channels
In mouse brain slices, voltage-clamp and current-clamp recordings measured a concentration-dependent depolarisation of gonadotropin-releasing-hormone neurons, with the underlying current traced to the inhibition of inwardly rectifying potassium channels and the activation of TRPC-like cationic channels as measured endpoints.
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Links open the original study on PubMed. For research and educational purposes, descriptive of the published preclinical literature, not therapeutic claims about any ai-peptides product. A Certificate of Analysis and a Safety Data Sheet are available on request for every batch.
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