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BPC-157 is a synthetic pentadecapeptide derived from a protective fragment of gastric juice protein, stable in acidic conditions.
In the published literature, BPC-157 has been characterised in preclinical models examining angiogenesis and the vascular endothelial growth factor and nitric oxide pathways. It is supplied as a research compound and is not intended for human or veterinary use.
BPC-157 has been characterised in preclinical laboratory models. The primary studies below, in animal and in-vitro tendon and ligament models, examined biomechanical, histological, and cellular endpoints, with proposed mechanisms including VEGF signalling, the nitric oxide system, angiogenesis, and the FAK-paxillin pathway. The literature is preclinical; it describes the compound, not any outcome in humans.
Animal and in vitro
Gastric pentadecapeptide BPC 157 and transected rat Achilles tendon with paired in vitro tendocyte culture
In a rat Achilles tendon transection model paired with cultured tendocytes, the peptide was studied for biomechanical, functional, and histological tissue endpoints and for tendocyte outgrowth in vitro, including its effect against the oxidative modulator 4-hydroxynonenal.
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Animal model
Stable gastric pentadecapeptide BPC 157 in a rat Achilles tendon-to-bone detachment model with a corticosteroid co-treatment arm
In a rat Achilles tendon-to-bone detachment model, the peptide was studied across functional, biomechanical, and microscopic tissue endpoints relative to saline controls and a corticosteroid (6-alpha-methylprednisolone) co-treatment arm.
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Animal and in vitro
Pentadecapeptide BPC 157, tendon-explant outgrowth, cell survival, and cell migration in rat tendon fibroblasts
In cultured rat Achilles tendon fibroblasts and a rat tendon model, the peptide was studied for tendon-explant outgrowth, cell survival under oxidative stress, and dose-dependent cell migration, with the proposed mechanism mapped to the FAK-paxillin signalling pathway.
Read the study ↗
Full documentation, on the record. A Certificate of Analysis and a Safety Data Sheet are available on request for every batch.
View the Certificate of Analysis ↗Links open the original study on PubMed. For research and educational purposes, descriptive of the published preclinical literature, not therapeutic claims about any ai-peptides product.
